Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study.

@article{Laan2015VariantsIA,
  title={Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study.},
  author={Sander W van der Laan and Hassan Foroughi Asl and Pleunie van den Borne and Jessica van Setten and M E Madeleine van der Perk and Sander M. van de Weg and Arjan H. Schoneveld and Dominique P. V. de Kleijn and Tom Michoel and Johan Bj{\"o}rkegren and Hester M. den Ruijter and Folkert W. Asselbergs and Paul I W de Bakker and G. Pasterkamp},
  journal={Atherosclerosis},
  year={2015},
  volume={239 2},
  pages={528-38}
}
BACKGROUND The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atherosclerosis. We assessed the impact of common variants in these genes on gene expression, circulating protein levels, and atherosclerotic plaque phenotypes. METHODS We included patients from the Stockholm Atherosclerosis Gene Expression study (STAGE, N = 109), and the… CONTINUE READING