Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome

@inproceedings{Lessard2013VariantsAM,
  title={Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sj{\"o}gren’s syndrome},
  author={Christopher James Lessard and He Li and Indra Adrianto and John A. Ice and Astrid Rasmussen and Kiely M. Grundahl and Jennifer Ann Kelly and Mikhail G. Dozmorov and Corinne Miceli-Richard and Simon J Bowman and Sue Lester and Per Eriksson and M L Eloranta and Johan G Brun and Lasse Gunnar G{\o}ransson and E. G. Harboe and Joel M Guthridge and Kenneth M Kaufman and Marika Kvarnstr{\"o}m and Helmi Jazebi and Deborah S. Cunninghame Graham and Martha E. Grandits and Abu N. M. Nazmul-Hossain and Ketan J Patel and Adam J. Adler and Jacen S. Maier-Moore and A Darise Farris and Michael T Brennan and James A. Lessard and James Chodosh and Rajaram Gopalakrishnan and Kimberly S. Hefner and Glen D. Houston and Andrew J W Huang and Pamela J. Hughes and David Michael Lewis and Lida Radfar and Michael D. Rohrer and Donald Ural Stone and Jonathan D. Wren and Timothy J Vyse and Patrick M Gaffney and Judith A James and Roald Omdal and Marie Wahren-Herlenius and Gabor G. Illei and Torsten Witte and Roland Jonsson and Maureen Rischmueller and Lars R{\"o}nnblom and Gunnel Nordmark and Wan-Fai Ng and Xavier Mariette and Juan-Manuel Anaya and Nelson L. Rhodus and Barbara M. Segal and Robert Hal Scofield and Courtney G Montgomery and John B. Harley and Kathy L. Moser Sivils},
  booktitle={Nature Genetics},
  year={2013}
}
Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjögren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10−114), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10−19), STAT4 (Pmeta = 6.80 × 10−15), IL12A (Pmeta = 1.17 × 10−10), FAM167A-BLK… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 127 CITATIONS

Genetics in Sjögren Syndrome.

  • Rheumatic diseases clinics of North America
  • 2016
VIEW 15 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

SLE redefined on the basis of molecular pathways.

  • Best practice & research. Clinical rheumatology
  • 2017
VIEW 16 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Epigenetic Signatures of Salivary Gland Inflammation in Sjögren's Syndrome

  • Arthritis & rheumatology
  • 2016
VIEW 3 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

The microbiome-systemic diseases connection.

  • Oral diseases
  • 2016
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2014
2019

CITATION STATISTICS

  • 13 Highly Influenced Citations

  • Averaged 24 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 81 REFERENCES

Two independent functional risk haplotypes in TNIP1 are associated with systemic lupus erythematosus

I Adrianto
  • Arthritis Rheum
  • 2012

Similar Papers

Loading similar papers…