Variant-specific [PSI+] infection is transmitted by Sup35 polymers within [PSI+] aggregates with heterogeneous protein composition.

@article{Bagriantsev2008VariantspecificI,
  title={Variant-specific [PSI+] infection is transmitted by Sup35 polymers within [PSI+] aggregates with heterogeneous protein composition.},
  author={Sviatoslav N Bagriantsev and Elena O. Gracheva and Janet E. Richmond and Susan W Liebman},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 6},
  pages={
          2433-43
        }
}
The [PSI(+)] prion is the aggregated self-propagating form of the Sup35 protein from the yeast Saccharomyces cerevisiae. Aggregates of Sup35 in [PSI(+)] cells exist in different heritable conformations, called "variants," and they are composed of detergent-resistant Sup35 polymers, which may be closely associated with themselves, other proteins, or both. Here, we report that disassembly of the aggregates into individual Sup35 polymers and non-Sup35 components increases their infectivity while… CONTINUE READING

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