Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells

@inproceedings{Conomos2012VariantRA,
  title={Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells},
  author={Dimitri Conomos and Michael D. Stutz and Mark Hills and Axel A. Neumann and Tracy M Bryan and Roger R Reddel and Hilda A Pickett},
  booktitle={The Journal of cell biology},
  year={2012}
}
Telomeres in cells that use the recombination-mediated alternative lengthening of telomeres (ALT) pathway elicit a DNA damage response that is partly independent of telomere length. We therefore investigated whether ALT telomeres contain structural abnormalities that contribute to ALT activity. Here we used next generation sequencing to analyze the DNA content of ALT telomeres. We discovered that variant repeats were interspersed throughout the telomeres of ALT cells. We found that the C-type… CONTINUE READING
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