Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

@article{Grant2006VariantOT,
  title={Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes},
  author={Struan F. A. Grant and Gudmar Thorleifsson and Inga Reynisdottir and Rafn Benediktsson and Andrei Manolescu and Jesus Sainz and Agnar Helgason and Hreinn Stef{\'a}nsson and Valur Emilsson and Anna Helgad{\'o}ttir and Unnur Styrkarsdottir and Kristinn Petur Magnusson and G. Bragi Walters and Ebba P{\'a}lsd{\'o}ttir and Thorbjorg Jonsdottir and Thorunn K Gudmundsd{\'o}ttir and Arnaldur Gylfason and Jona Saemundsdottir and Robert L. Wilensky and Muredach P. Reilly and Daniel J. Rader and Yu Zhao Bagger and Claus Christiansen and Vilmundur G. Gudnason and Gunnar Sigurdsson and Unnur Thorsteinsd{\'o}ttir and Jeffrey R. Gulcher and Augustine Kong and K{\'a}ri Stef{\'a}nsson},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={320-323}
}
We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7–like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes (P = 2.1 × 10−9). This was replicated in a Danish cohort (P = 4.8 × 10−3) and in a US cohort (P = 3.3 × 10−9). Compared… 
Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample
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The results strengthen the evidence that one or more variants in TCF7L2 are associated with increased risk of type 2 diabetes.
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Replicating evidence that variants in TCF7L2 increase the risk for type 2 diabetes and novel evidence that the variants likely influence both insulin secretion and insulin sensitivity are provided.
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TLDR
The authors' data strongly confirm that variants of the TCF7L2 gene contribute to the risk of type 2 diabetes.
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TLDR
The data suggest that the TCF7L2 gene is an important factor regulating insulin secretion, which could explain its association with type 2 diabetes.
Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians.
TLDR
In Japanese-Brazilians, a population with a high prevalence of type 2 diabetes, common TCF7L2 variants did not make major contributions to the incidence of glucose tolerance abnormalities, and it was found that carriers of the CT genotype for rs7903146 had significantly lower insulin levels 2 h after a 75-g glucose load than carriers of.
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TLDR
Evidence is provided that variation in the TCF7L2 genomic region may affect risk for type 2 diabetes in Mexican Americans, but the attributable risk may be lower than in Caucasian populations.
Transcription Factor TCF7L2 Genetic Study in the French Population
TLDR
Evidence is provided that TCF7L2 is a major determinant of type 2 diabetes risk in European populations and suggests that this transcription factor plays a key role in glucose homeostasis.
Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men
TLDR
The findings confirm that the TCF7L2 gene represents an important locus for predicting inherited susceptibility to type 2 diabetes.
Transcription factor 7-like 2 (TCF7L2) gene polymorphisms are strong predictorsof type 2 diabetes among nonobese diabetics in the Turkish population.
TLDR
The results indicate that, in the Turkish population, the T allele of the rs7903146 (C → T) and rs12255372 (G →T) polymorphisms in the TCF7L2 gene is an independent risk factor for the development of T2D.
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