Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

  title={Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes},
  author={Struan F. A. Grant and Gudmar Thorleifsson and Inga Reynisd{\'o}ttir and Rafn Benediktsson and Andrei Manolescu and J. A. Garc{\'i}a S{\'a}inz and Agnar Helgason and Hreinn Stefansson and Valur Emilsson and Anna Helgadottir and Unnur Styrkarsdottir and Kristinn P. Magnusson and G Bragi Walters and Ebba P{\'a}lsd{\'o}ttir and Thorbjorg Jonsdottir and Thorunn K Gudmundsd{\'o}ttir and Arnaldur Gylfason and Jona Saemundsdottir and Robert L. Wilensky and Muredach P. Reilly and Daniel J. Rader and Yu Zhao Bagger and Claus Christiansen and Vilmundur Gudnason and Gunnar Sigurdsson and Unnur Thorsteinsdottir and Jeffrey Robert Gulcher and Augustine Kong and K{\'a}ri Stef{\'a}nsson},
  journal={Nature Genetics},
We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7–like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes (P = 2.1 × 10−9). This was replicated in a Danish cohort (P = 4.8 × 10−3) and in a US cohort (P = 3.3 × 10−9). Compared… CONTINUE READING
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