Variant of TREM2 associated with the risk of Alzheimer's disease.

  title={Variant of TREM2 associated with the risk of Alzheimer's disease.},
  author={Thorl{\'a}kur J{\'o}nsson and Hreinn Stefansson and Stacy Steinberg and Ingileif J{\'o}nsd{\'o}ttir and Palmi V. Jonsson and J{\'o}n Snaedal and Sigurbjorn Bjornsson and Johanna Huttenlocher and Allan I. Levey and James J Lah and Dan Rujescu and Harald Hampel and Ina Giegling and Ole A. Andreassen and Knut Engedal and Ingun Dina Ulstein and Srdjan Djurovic and Carla Ibrahim-Verbaas and Albert Hofman and M. Arfan Ikram and Cornelia M van Duijn and Unnur Thorsteinsdottir and Augustine Kong and K{\'a}ri Stef{\'a}nsson},
  journal={The New England journal of medicine},
  volume={368 2},
BACKGROUND Sequence variants, including the ε4 allele of apolipoprotein E, have been associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants affecting the risk of late-onset Alzheimer's disease have been found. METHODS We obtained the genome sequences of 2261 Icelanders and identified sequence variants that were likely to affect protein function. We imputed these variants into the genomes of patients with Alzheimer's disease and control participants… CONTINUE READING
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