Variant eotaxin: its effects on the asthma phenotype.

  title={Variant eotaxin: its effects on the asthma phenotype.},
  author={Hidetoshi Nakamura and Andrew D Luster and Takanori Nakamura and Kwang Ho In and Larry A. Sonna and Aaron Deykin and Helene M Langevin and Jeffrey M Drazen and Craig M. Lilly},
  journal={The Journal of allergy and clinical immunology},
  volume={108 6},
BACKGROUND Eotaxin, a CC chemokine expressed in the asthmatic lung, has been associated with impaired lung function. The role of its variant form is unknown. OBJECTIVE The purpose of this study was to detect the population frequency and effects of a known single-nucleotide polymorphism in the eotaxin gene in which a threonine residue (THR(23)) is substituted for the wild-type alanine (ALA(23)) at the 23rd amino acid at the terminus of the peptide leader sequence. METHODS We measured eotaxin… CONTINUE READING