Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination.

@article{Bath2008VariantBN,
  title={Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination.},
  author={Kevin G. Bath and Nathalie Mandairon and Deqiang Q Jing and Rithwick Rajagopal and Ruchi Kapoor and Zhe-yu Chen and Tanvir Khan and Catia C. Proenca and Rosemary T. Kraemer and Thomas A. Cleland and Barbara L. Hempstead and Moses V Chao and Francis B. S. Lee},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 10},
  pages={2383-93}
}
Neurogenesis, the division, migration, and differentiation of new neurons, occurs throughout life. Brain derived neurotrophic factor (BDNF) has been identified as a potential signaling molecule regulating neurogenesis in the subventricular zone (SVZ), but its functional consequences in vivo have not been well defined. We report marked and unexpected deficits in survival but not proliferation of newly born cells of adult knock-in mice containing a variant form of BDNF [a valine (Val) to… CONTINUE READING

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