Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity.

@article{Liu2007VariantIR,
  title={Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity.},
  author={Gang Liu and Yuko Tsuruta and Zhiqian Gao and Young-Jun Park and Edward Abraham},
  journal={Journal of immunology},
  year={2007},
  volume={179 6},
  pages={4125-34}
}
IL-1R-associated kinase (IRAK)-1 is a critical mediator of TLR/IL-1R-induced activation of the transcription factor NF-kappaB. We previously described that a commonly occurring IRAK-1 variant haplotype, containing amino acid changes from serine to phenylalanine at position 196 and from leucine to serine at position 532, is associated with increased activation of NF-kappaB in LPS-stimulated neutrophils from patients with sepsis-induced acute lung injury and also higher mortality and more severe… CONTINUE READING