Variant Creutzfeldt–Jakob disease

@article{Ironside2010VariantCD,
  title={Variant Creutzfeldt–Jakob disease},
  author={J. W. Ironside},
  journal={Haemophilia},
  year={2010},
  volume={16}
}
Summary.  Variant Creutzfeldt–Jakob disease (CJD) is an emerging form of human prion disease caused by oral exposure to the bovine spongiform encephalopathy agent. Most cases have occurred in the UK, but smaller numbers of cases have been identified in 10 other countries worldwide. All confirmed cases belong to a single genetic subgroup defined by methionine homozygosity at codon 129 in the prion protein gene. Variant CJD has a widespread distribution of infectivity in the body, involving… 

The importance of ongoing international surveillance for Creutzfeldt–Jakob disease

TLDR
An up-to-date overview of the transmission of prion diseases in human populations is provided and it is argued that CJD surveillance remains vital both from a public health perspective and to support essential research into disease pathophysiology, enhanced diagnostic tests and much-needed treatments.

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TLDR
Clinical features of six cases of the sporadic form of CJD with definitive diagnosis by histopathology, and five cases with probable diagnosis were reported in patients treated at the Peruvian National Institute of Neurological Sciences.

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TLDR
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TLDR
Keeping instruments moist was estimated to reduce the risk of surgically transmitted Creutzfeldt-Jakob disease cases and associated costs, and the estimated costs per quality-adjusted life-year gained of these strategies in addition to keeping instruments moist were in excess of £1M.

Hemophilia A and Hemophilia B

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For certain rare diseases, VHA information systems can be used to assemble a substantive case series for clinical study, however, the VHA's distinctive demographic characteristics and population dynamics may limit the external validity of epidemiologic investigations.

Infections of the Nervous System

TLDR
It is essential that the key features of these conditions are understood by critical care professionals and others to prevent a missed diagnosis and by those who may work in those parts of the world where these infections are more common.

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