Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium.

@article{Wolpin2010VariantAB,
  title={Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium.},
  author={Brian Wolpin and Peter Kraft and Mousheng Xu and Emily Steplowski and Martin L Olsson and Alan A. Arslan and Hendrik Bas Bueno-de-Mesquita and Myron Gross and Kathy J. Helzlsouer and Eric J Jacobs and Andrea Z LaCroix and G. M. van Petersen and Rachael Z. Stolzenberg-Solomon and Wei Zheng and Demetrius Albanes and Naomi E. Allen and Laufey T Amundadottir and Melissa A Austin and Marie-Christine Boutron-Ruault and Julie E. Buring and Frederico Canzian and Stephen J. Chanock and J. Michael Gaziano and Edward L. Giovannucci and G{\"o}ran Hallmans and Susan E. Hankinson and Robert Nathaniel Hoover and David J. Hunter and Amy A. Hutchinson and Kevin B. Jacobs and Charles Kooperberg and Julie Bloch Mendelsohn and Dominique S. Michaud and Kim Overvad and Alpa V. Patel and M P{\'e}rez S{\'a}nchez and Leah B. Sansbury and Xiao-ou Shu and Nadia Slimani and Geoffrey S. Tobias and Dimitirios Trichopoulos and Paolo Vineis and Kala Visvanathan and Jarmo R Virtamo and Jean Wactawski-Wende and Joanne L. Watters and Kai Yu and Anne Zeleniuch-Jacquotte and Patricia A Hartge and Charles S. Fuchs},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2010},
  volume={19 12},
  pages={3140-9}
}
BACKGROUND Subjects with non-O ABO blood group alleles have increased risk of pancreatic cancer. Glycosyltransferase activity is greater for the A(1) versus A(2) variant, whereas O01 and O02 variants are nonfunctioning. We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotype would modify the association with risk. METHODS We determined ABO variants and secretor… CONTINUE READING

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