Variance prediction in SPECT reconstruction based on the Fisher information using a novel angular blurring algorithm for computation of the system matrix


In this paper we propose a Gaussian decomposition approach to compute the SPECT imaging system matrix. The flexibility of our method allows the implementation of a wide range of imaging systems. With the system matrix, we predict the variance in reconstructed images using the Fisher information matrix and local block circulant approximation. We present… (More)

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