Variance heterogeneity analysis for detection of potentially interacting genetic loci: method and its limitations

@inproceedings{Struchalin2010VarianceHA,
  title={Variance heterogeneity analysis for detection of potentially interacting genetic loci: method and its limitations},
  author={Maksim V. Struchalin and Abbas Dehghan and Jacqueline C. M. Witteman and Cornelia M van Duijn and Yurii S. Aulchenko},
  booktitle={BMC Genetics},
  year={2010}
}
Presence of interaction between a genotype and certain factor in determination of a trait's value, it is expected that the trait's variance is increased in the group of subjects having this genotype. Thus, test of heterogeneity of variances can be used as a test to screen for potentially interacting single-nucleotide polymorphisms (SNPs). In this work, we evaluated statistical properties of variance heterogeneity analysis in respect to the detection of potentially interacting SNPs in a case… CONTINUE READING

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