Variance estimation in the analysis of microarray data.

@article{Wang2009VarianceEI,
  title={Variance estimation in the analysis of microarray data.},
  author={Yuedong Wang and Yanyuan Ma and Raymond J. Carroll},
  journal={Journal of the Royal Statistical Society. Series B, Statistical methodology},
  year={2009},
  volume={71 2},
  pages={
          425-445
        }
}
Microarrays are one of the most widely used high throughput technologies. One of the main problems in the area is that conventional estimates of the variances that are required in the t-statistic and other statistics are unreliable owing to the small number of replications. Various methods have been proposed in the literature to overcome this lack of degrees of freedom problem. In this context, it is commonly observed that the variance increases proportionally with the intensity level, which… CONTINUE READING
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