Variable ventilation induces endogenous surfactant release in normal guinea pigs.

@article{Arold2003VariableVI,
  title={Variable ventilation induces endogenous surfactant release in normal guinea pigs.},
  author={Stephen P. Arold and B{\'e}la Suki and Adriano Mesquita Alencar and Kenneth R. Lutchen and Edward P. Ingenito},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2003},
  volume={285 2},
  pages={
          L370-5
        }
}
  • S. Arold, B. Suki, +2 authors E. Ingenito
  • Published 1 August 2003
  • Medicine, Engineering
  • American journal of physiology. Lung cellular and molecular physiology
Variable or noisy ventilation, which includes random breath-to-breath variations in tidal volume (Vt) and frequency, has been shown to consistently improve blood oxygenation during mechanical ventilation in various models of acute lung injury. To further understand the effects of variable ventilation on lung physiology and biology, we mechanically ventilated 11 normal guinea pigs for 3 h using constant-Vt ventilation (n = 6) or variable ventilation (n = 5). After 3 h of ventilation, each animal… 
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94 Citations
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94 Citations

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VV2 outperformed VV1 by enhancing SP-B metabolism resulting in open alveolar airspaces, less leakage and inflammation and hence better respiratory mechanics, and is tested for optimal performance in a preterm lamb model.
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Variable ventilation improves ventilation efficiency and in vivo lung compliance in the preterm lung, but unlike adult models, had no effect on arterial oxygenation.
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It is found that maintaining epithelial cell stretch above a critical threshold with either PEEP or VT may help stabilize the injured lung and demonstrate the significance of patient-ventilator coupling through the influence of cellular stretch-induced surfactant release on the whole lung stability.
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TLDR
The impact of variable ventilation on lung function and histologic damage, as well as markers of lung inflammation, epithelial and endothelial cell damage, and alveolar stress, and bacterial translocation in experimental pneumonia are investigated.
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TLDR
Variable ventilation improves ventilation efficiency and in vivo lung compliance in the ovine preterm lung without increasing lung inflammation or lung injury.
Effects of variable versus nonvariable controlled mechanical ventilation on pulmonary inflammation in experimental acute respiratory distress syndrome in pigs
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TLDR
Noisy ventilation with variable Vt and fixed respiratory frequency improves respiratory function and reduces histological damage compared with standard protective ventilation strategies.
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TLDR
The application of VV in a large animal model of lung injury results in improved gas exchange and superior lung mechanics in comparison with CV that can be explained at least partially by the long-lasting effects of the recruitments occurring during VV.
Noisy Ventilation Improves Lung Function
TLDR
Not only did noisy ventilation induce endogenous surfactant release, but also the standard deviation of the noise appears to be directly related to the magnitude of improvements seen with this ventilation modality in a manner similar to stochastic resonance.
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References

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