Variable steroid receptor responses: Intrinsically disordered AF1 is the key

  title={Variable steroid receptor responses: Intrinsically disordered AF1 is the key},
  author={S. Stoney Simons and Raj Kumar},
  journal={Molecular and Cellular Endocrinology},
Steroid hormones, acting through their cognate receptor proteins, see widespread clinical applications due to their ability to alter the induction or repression of numerous genes. However, steroid usage is limited by the current inability to control off-target, or non-specific, side-effects. Recent results from three separate areas of research with glucocorticoid and other steroid receptors (cofactor-induced changes in receptor structure, the ability of ligands to alter remote regions of… CONTINUE READING

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