Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharide.

@article{Lucas1994VariableRS,
  title={Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharide.},
  author={Alexander H. Lucas and James W. Larrick and Donald C. Reason},
  journal={Infection and immunity},
  year={1994},
  volume={62 9},
  pages={3873-80}
}
A hybridoma secreting a human immunoglobulin G2 kappa monoclonal antibody (MAb) specific for the capsular polysaccharide of Haemophilus influenzae type b (Hib) was isolated. This MAb, designated CA4, was bactericidal to Hib in vitro and protected infant rats from Hib bacteremia. Nucleotide sequence analysis of CA4 variable (V) region cDNA showed that the… CONTINUE READING