Variable region gene segment utilization in rhesus monkey hybridomas producing human red blood cell-specific antibodies: predominance of the VH4 family but not VH4-21 (V4-34).

@article{Andris1997VariableRG,
  title={Variable region gene segment utilization in rhesus monkey hybridomas producing human red blood cell-specific antibodies: predominance of the VH4 family but not VH4-21 (V4-34).},
  author={Jennifer S. Andris and Amy Barnhart Miller and Sajith Abraham and Susan M. Cunningham and Francis Roubinet and Antoine Blancher and J. Donald Capra},
  journal={Molecular immunology},
  year={1997},
  volume={34 3},
  pages={237-53}
}
Structural analyses of human immunoglobulin gene segments from monoclonal cell lines provide valuable information regarding the antibody repertoire. This information, in conjunction with a nearly complete knowledge of the human immunoglobulin germline repertoire, now allows further investigation into the underlying molecular basis responsible for some of the observed biases found in the expressed repertoire. One human heavy chain variable region gene segment, V4-34 (VH4-21), is one of the most… CONTINUE READING

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