Variable promoter region CpG island methylation of the putative tumor suppressor gene Connexin 26 in breast cancer.

@article{Tan2002VariablePR,
  title={Variable promoter region CpG island methylation of the putative tumor suppressor gene Connexin 26 in breast cancer.},
  author={Lor-wai Tan and Tina Bianco and Alexander Dobrovic},
  journal={Carcinogenesis},
  year={2002},
  volume={23 2},
  pages={231-6}
}
Intercellular communication via gap junctions is a mechanism for tumor suppression. Connexin 26 (Cx26) is a structural component of gap junctions expressed by breast epithelial cells. Expression levels of Cx26 are reduced in many breast tumors. Methylation-sensitive single-stranded conformation analysis showed variable methylation in the promoter region CpG island in 11 out of 20 (55%) breast cancer patients. Heterogeneity in methylation patterns was observed both between and within tumors. The… CONTINUE READING

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