Variable oral absorption of cyclosporine. A biopharmaceutical risk factor for chronic renal allograft rejection.

@article{Kahan1996VariableOA,
  title={Variable oral absorption of cyclosporine. A biopharmaceutical risk factor for chronic renal allograft rejection.},
  author={Barry D. Kahan and Marilyn C. Welsh and Linda Schoenberg and Lynne P. Rutzky and Sheila Moriber Katz and Diana L. Urbauer and Charles T Van Buren},
  journal={Transplantation},
  year={1996},
  volume={62 5},
  pages={
          599-606
        }
}
The inter- and intrapatient variability in cyclosporine (CsA) pharmacokinetics obfuscates the relationship between therapeutic outcome and administered dose, thereby impeding the development of secure algorithms for CsA therapy. In an attempt to understand these variabilities, we previously performed serial pharmacokinetic profiles on 160 renal transplant recipients during the first 3 posttransplant months. Drug exposure was estimated by the average CsA concentration (Cav), which was defined as… CONTINUE READING
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