Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer.

@article{Yoon2002VariableLO,
  title={Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer.},
  author={Dae-Sung Yoon and Robert P. Wersto and Weibo Zhou and Francis J. Chrest and Elizabeth S. Garrett and Teag Kyu Kwon and Edward W. Gabrielson},
  journal={The American journal of pathology},
  year={2002},
  volume={161 2},
  pages={391-7}
}
Cytogenetic analyses have revealed that many aneuploid breast cancers have cell-to-cell variations of chromosome copy numbers, suggesting that these neoplasms have instability of chromosome numbers. To directly test for possible chromosomal instability in this disease, we used fluorescent in situ hybridization to monitor copy numbers of multiple chromosomes in cultures of replicating breast cancer-derived cell lines and nonmalignant breast epithelial cells. While most (7 of 9) breast cancer… CONTINUE READING

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