Variable interactions between protein crowders and biomolecular solutes are important in understanding cellular crowding.

@article{Feig2012VariableIB,
  title={Variable interactions between protein crowders and biomolecular solutes are important in understanding cellular crowding.},
  author={Michael Feig and Yuji Sugita},
  journal={The journal of physical chemistry. B},
  year={2012},
  volume={116 1},
  pages={599-605}
}
The effect of cellular crowding was examined from molecular dynamics simulations of chymotrypsin inhibitor 2 (CI2) in the presence of either lysozyme or bovine serum albumin (BSA) crowder molecules as a complement to recent experimental studies of the same systems (Miklos, A. C.; Sarkar, M.; Wang, Y.; Pielak, G. J. J. Am. Chem. Soc.2011, 133, 7116). The simulations confirm a destabilization and significantly slowed diffusion of CI2 in the presence of lysozyme and indicate that this observation… CONTINUE READING