Variable inactivation of human factor VIII from different sources by human factor VIII inhibitors.

Abstract

The source of human factor VIIII (FVIII) had a marked effect on the inhibitory activity of a panel of eight human FVIII inhibitors. Use of conventional FVIII concentrates gave lower inhibitor titres whereas a monoclonal antibody purified FVIII concentrate gave titres similar to or greater than those with plasma. Addition of phospholipid (PL) protected highly purified FVIII against inhibition. The content of PL-bound FVIII in concentrates may account for the observed differences.

Cite this paper

@article{Littlewood1991VariableIO, title={Variable inactivation of human factor VIII from different sources by human factor VIII inhibitors.}, author={Janet D Littlewood and Sally A Bevan and Geoff Kemball-Cook and Robert J. Evans and Trevor W. Barrowcliffe}, journal={British journal of haematology}, year={1991}, volume={77 4}, pages={535-8} }