Variable expression of microglial DAP12 and TREM2 genes in Nasu-Hakola disease

@article{Sasaki2015VariableEO,
  title={Variable expression of microglial DAP12 and TREM2 genes in Nasu-Hakola disease},
  author={Kazunari Sasaki and Akiyoshi Kakita and Kunihiro Yoshida and T Konno and Takeshi Ikeuchi and Shintaro Hayashi and Hidenori Matsuo and Kei Shioda},
  journal={neurogenetics},
  year={2015},
  volume={16},
  pages={265-276}
}
Nasu-Hakola disease (NHD) is a form of presenile dementia associated with sclerosing leukoencephalopathy and polycystic lipomembranous osteodysplasia. This extremely rare inherited disease is caused by mutations in either DAP12 or TREM2. The present study was designed to assess the relationship between DAP12/TREM2 genotype, mRNA and protein expression levels by both Western blotting and immunohistochemistry, and the tissue distribution and pathomorphological phenotype of the microglia… CONTINUE READING

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