Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children.

@article{Cohen2010VariableDO,
  title={Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children.},
  author={Pinchas Cohen and John A. Germak and Alan D Rogol and Wayne Weng and A M Kappelgaard and Ron G. Rosenfeld},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2010},
  volume={95 5},
  pages={2089-98}
}
CONTEXT We recently showed that, in IGF-based GH therapy, the IGF-I target chosen affects GH dose requirements, and higher IGF-I targets are associated with more robust growth parameters. OBJECTIVE The objective of the study was to compare the response of GH-deficient (GHD) vs. idiopathic short-stature (ISS) children to IGF-based GH therapy. DESIGN This was a 2-yr, open-label, randomized trial. SETTING The setting was multicenter and outpatient. PATIENTS Prepubertal short children… CONTINUE READING

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