Variable coordination of cotranscribed genes in Escherichia coli following antisense repression

  title={Variable coordination of cotranscribed genes in Escherichia coli following antisense repression},
  author={Rikard Dryselius and Abbas Nikravesh and Agn{\'e} Kulyt{\'e} and Shan Goh and L. Good},
  journal={BMC Microbiology},
  pages={97 - 97}
A majority of bacterial genes belong to tight clusters and operons, which complicates gene functional studies using conventional knock-out methods. Antisense agents can down-regulate the expression of genes without disrupting the genome because they bind mRNA and block its expression. However, it is unclear how antisense inhibition affects expression from genes that are cotranscribed with the target. To examine the effects of antisense inhibition on cotranscribed genes, we constructed a plasmid… CONTINUE READING
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Publications referenced by this paper.
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Polarity effects in the lactose operon of Escherichia coli.

Journal of molecular biology • 2004
View 1 Excerpt

Genome size and operon content.

Journal of theoretical biology • 2003
View 2 Excerpts