Variable cardiac α-actin (Actc1) expression in early adult skeletal muscle correlates with promoter methylation.


Different genes encode the α-actin isoforms that are predominantly expressed in heart and skeletal muscle. Mutations in the skeletal muscle α-actin gene (ACTA1) cause muscle diseases that are mostly lethal in the early postnatal period. We previously demonstrated that the disease phenotype of ACTA1 mouse models could be rescued by transgenic over-expression… (More)
DOI: 10.1016/j.bbagrm.2017.08.004


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