Variable association between genetic variation in the CYP7 gene promoter and plasma lipoproteins in three Canadian populations.

@article{Hegele1999VariableAB,
  title={Variable association between genetic variation in the CYP7 gene promoter and plasma lipoproteins in three Canadian populations.},
  author={Robert A Hegele and Jinyu Wang and Stewart B Harris and J. Howard Brunt and Terence K. Young and Anthony J. G. Hanley and Bernard Zinman and Philip W. Connelly and Christen M. Anderson},
  journal={Atherosclerosis},
  year={1999},
  volume={154 3},
  pages={
          579-87
        }
}
The promoter sequence variant -278A in the CYP7 gene, which encodes cholesterol 7-alpha hydroxylase, was previously reported to be associated with reduced plasma low density lipoprotein (LDL) cholesterol concentration. We tested for association of CYP7-278A with plasma lipoprotein traits in samples taken from three distinct Canadian populations: 594 Alberta Hutterites, 325 Ontario Oji-Cree and 190 Keewatin Inuit. The CYP7-278A allele frequencies in these three groups were 0.708, 0.466 and 0.490… CONTINUE READING
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Association of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients.

  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2009
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CITES BACKGROUND

Genetic determinants of plasma lipoproteins

  • Nature Clinical Practice Cardiovascular Medicine
  • 2007

Cholesterol-metabolizing cytochromes P450.

  • Drug metabolism and disposition: the biological fate of chemicals
  • 2006
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