Variable activation of the DNA damage response pathways in patients undergoing single-photon emission computed tomography myocardial perfusion imaging.

@article{Lee2015VariableAO,
  title={Variable activation of the DNA damage response pathways in patients undergoing single-photon emission computed tomography myocardial perfusion imaging.},
  author={Won Hee Lee and Patricia K. Nguyen and Shijun Hu and Grace Y Liang and Sang-Ging Ong and Leng Han and Veronica Sanchez-Freire and Andrew Stephen Lee and Minal Vasanawala and George M. Segall and Joseph C Wu},
  journal={Circulation. Cardiovascular imaging},
  year={2015},
  volume={8 2},
  pages={e002851}
}
BACKGROUND Although single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) has improved the diagnosis and risk stratification of patients with suspected coronary artery disease, it remains a primary source of low-dose radiation exposure for cardiac patients. To determine the biological effects of low-dose radiation from SPECT MPI, we measured the activation of the DNA damage response pathways using quantitative flow cytometry and single-cell gene expression… CONTINUE READING
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