Variable Responses of MYC Translocation Positive Lymphoma Cell Lines To Different Combinations of Novel Agents: Impact of BCL2 Family Protein Expression

@article{Deng2018VariableRO,
  title={Variable Responses of MYC Translocation Positive Lymphoma Cell Lines To Different Combinations of Novel Agents: Impact of BCL2 Family Protein Expression},
  author={Wenhan Deng and Alexandra Clipson and Hongxiang Liu and Yuanxue Huang and Rachel Dobson and Ming Wang and Peter Johnson and Ming-Qing Du},
  journal={Translational Oncology},
  year={2018},
  volume={11},
  pages={1147 - 1154}
}
Several newly developed drugs including JQ1 (BET inhibitor), ABT199 (BCL2 inhibitor), and bortezomib (proteasome inhibitor) may offer novel therapeutic strategies for aggressive diffuse large B-cell lymphoma (DLBCL). We tested these drugs together with doxorubicin in a series of combinations in 16 DLBCL cell lines including 4 ABC-DLBCL (OCI-Ly3, OCI-Ly10, SUDHL2, RIVA) and 12 GCB-DLBCL lines (OCI-Ly4, OCI-Ly18, BJAB, SUDHL4, SUDHL6, SUDHL10, DB, PR1, VAL, SC1, Karpas-231, Karpas-422). Among… Expand
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Product Data Sheet Chemical Properties Product
Chemical Name: N,N,2-trimethyl-5-nitrobenzenesulfonamide Canonical SMILES: CC1=C(S(N(C)C)(=O)=O)C=C(N(=O)=O)C=C1 Solubility: Soluble in DMSO Storage: Store at -20°C General tips: For obtaining aExpand

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