Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb

@article{Dam2003VariableMC,
  title={Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb},
  author={J J M Ten Dam and Rongjin Guan and Kannan Natarajan and Nazzareno Dimasi and Lukasz K. Chlewicki and David M. Kranz and Peter Schuck and David H Margulies and Roy A. Mariuzza},
  journal={Nature Immunology},
  year={2003},
  volume={4},
  pages={1213-1222}
}
The Ly49 family of natural killer (NK) receptors regulates NK cell function by sensing major histocompatibility complex (MHC) class I. Ly49 receptors show complex patterns of MHC class I cross-reactivity and, in certain cases, peptide selectivity. To investigate whether specificity differences result from topological differences in MHC class I engagement, we determined the structure of the peptide-selective receptor Ly49C in complex with H-2Kb. The Ly49C homodimer binds two MHC class I… CONTINUE READING