Variable Cyst Development in Autosomal Dominant Polycystic Kidney Disease: The Biologic Context.

@article{Leonhard2016VariableCD,
  title={Variable Cyst Development in Autosomal Dominant Polycystic Kidney Disease: The Biologic Context.},
  author={Wouter N. Leonhard and H. Kevin Happe and Dorien J. M. Peters},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2016},
  volume={27 12},
  pages={3530-3538}
}
Patients with autosomal dominant polycystic kidney disease (ADPKD) typically carry a mutation in either the PKD1 or PKD2 gene, which leads to massive cyst formation in both kidneys. However, the large intrafamilial variation in the progression rate of ADPKD suggests involvement of additional factors other than the type of mutation. The identification of these factors will increase our understanding of ADPKD and could ultimately help in the development of a clinically relevant therapy. Our… CONTINUE READING
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