Variability of the paraoxonase gene (PON1) in Euro- and Afro-Brazilians.

  title={Variability of the paraoxonase gene (PON1) in Euro- and Afro-Brazilians.},
  author={Karla V Allebrandt and Ricardo Lehtonen Rodrigues de Souza and Eleidi Alice Chautard-Freire-Maia},
  journal={Toxicology and applied pharmacology},
  volume={180 3},
The human high-density lipoprotein-associated paraoxonase (EC; PON1) plays a role in the hydrolysis of organophosphorus compounds and against the oxidative damage of low-density lipoprotein. In the present study, variants of PON1 (55 and 192) were investigated by PCR-RFLP and PCR-SSCA in Euro- (N = 101) and Afro-Brazilians (N = 70). The PON1*55 and PON1*192 allele frequencies were significantly different in these ethnic groups (p < 0.05 and p < 0.001, respectively). The genotype… CONTINUE READING