Variability of the immunologic and clinical response in dystonic patients immunoresistant to botulinum toxin injections.

@article{Sankhla1998VariabilityOT,
  title={Variability of the immunologic and clinical response in dystonic patients immunoresistant to botulinum toxin injections.},
  author={Charu Sankhla and Joseph Jankovic and Derek Duane},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={1998},
  volume={13 1},
  pages={150-4}
}
Immunoresistance (Ab+) to botulinum toxin type A (BTX-A) has been a serious concern since the introduction of BTX-A in the treatment of dystonia and other disorders associated with abnormal muscle contractions. We studied seven patients who developed Ab+ and later reverted to antibody-negative (Ab-) status. These seven patients, six women (mean age, 56 years; range, 41-80 years), with an average duration of dystonia for all patients of 197 months (range, 84-360 months), received a total mean… CONTINUE READING

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