Variability of the alloreactive T-cell response to human leukemic blasts.

@article{Delain1994VariabilityOT,
  title={Variability of the alloreactive T-cell response to human leukemic blasts.},
  author={Martine Delain and Pierre Tiberghien and Evelyne Racadot and Maryse Billot and J Pariset and Jacqueline Chabod and J Y Cahn and Patrick Herv{\'e}},
  journal={Leukemia},
  year={1994},
  volume={8 4},
  pages={642-7}
}
Clinical and experimental data suggest a role for the immune response in preventing leukemic relapses after allogeneic bone marrow transplantation (BMT): the graft-versus-leukemia (GVL) effect. In this report, we have evaluated the response of normal donor lymphocytes against allogeneic leukemic cells as an in vitro model of the GVL effect. We used a limiting dilution technique in order to determine the frequency of cytotoxic T-lymphocyte precursors (pre-CTL) against allogeneic leukemic blasts… CONTINUE READING

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