Variability of the alloreactive T-cell response to human leukemic blasts.

  title={Variability of the alloreactive T-cell response to human leukemic blasts.},
  author={Martine Delain and Pierre Tiberghien and Evelyne Racadot and Maryse Billot and J Pariset and Jacqueline Chabod and J Y Cahn and Patrick Herv{\'e}},
  volume={8 4},
Clinical and experimental data suggest a role for the immune response in preventing leukemic relapses after allogeneic bone marrow transplantation (BMT): the graft-versus-leukemia (GVL) effect. In this report, we have evaluated the response of normal donor lymphocytes against allogeneic leukemic cells as an in vitro model of the GVL effect. We used a limiting dilution technique in order to determine the frequency of cytotoxic T-lymphocyte precursors (pre-CTL) against allogeneic leukemic blasts… CONTINUE READING


Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…