Variability of sexual phenotype in 46,XX(SRY+) patients: the influence of spreading X inactivation versus position effects.

@article{Sharp2005VariabilityOS,
  title={Variability of sexual phenotype in 46,XX(SRY+) patients: the influence of spreading X inactivation versus position effects.},
  author={Alana Sharp and Kamila Kusz and Jadwiga Jaruzelska and William Tapper and Maria Szarras-Czapnik and Jacek Wolski and P Jacobs},
  journal={Journal of medical genetics},
  year={2005},
  volume={42 5},
  pages={420-7}
}
D uring male meiosis the X and Y chromosomes pair along much of their length, with a single obligatory recombination event usually occurring in the pseudoautosomal region (PAR) at the tip of Xp and Yp, thus maintaining identity of the sex chromosome PARs. Occasionally illegitimate crossover occurs outside the PAR, resulting in the transfer of Y specific sequences onto the X chromosome. Such translocations between distal Xp and Yp occur relatively frequently, resulting in the generation of 46,XX… CONTINUE READING

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