Variability of response to lithium augmentation in refractory depression.

  title={Variability of response to lithium augmentation in refractory depression.},
  author={Lawrence H Price and Dennis S. Charney and George R. Heninger},
  journal={The American journal of psychiatry},
  volume={143 11},
Eighty-four patients with major depression refractory to a controlled antidepressant trial had lithium added to their ongoing treatment. Objective symptom ratings showed highly significant improvement in the sample as a whole. At discharge or after 24 days, 31% of the patients showed a marked response, 25% a partial response. Thus, 56% of patients had a significant positive response, while 44% were nonresponders. This study indicates that response to lithium augmentation may be quite variable… 

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