Variability of inversion of (R)-flurbiprofen in different species.

@article{MenzelSoglowek1992VariabilityOI,
  title={Variability of inversion of (R)-flurbiprofen in different species.},
  author={S. Menzel-Soglowek and Gerd Geisslinger and Winfried S. Beck and Kay Brune},
  journal={Journal of pharmaceutical sciences},
  year={1992},
  volume={81 9},
  pages={
          888-91
        }
}
The anti-inflammatory activity of 2-arylpropionic acids like flurbiprofen appears to be due to the S enantiomers only. A unique characteristic of the metabolism of this class of drugs is inversion of configuration. The present study examines whether chiral inversion occurs after administration of the optically pure flurbiprofen enantiomers to various species (i.e., dogs, guinea pigs, rats, and gerbils). Concentrations of the enantiomers in plasma were analyzed by a stereoselective high… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Similar Papers

Loading similar papers…