Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder

  title={Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder},
  author={Bernard Lerer and Fabio Macciardi and Ronnen H. Segman and Rolf Adolfsson and Douglas Blackwood and Sylvie Blairy and Jurgen Del Favero and Dimitris G. Dikeos and Radka Kaneva and Roberta Lilli and Isabelle Massat and Vihra K. Milanova and Walter Muir and Markus M. N{\"o}then and Lilijana Oru{\vc} and Tatyana Petrova and George Papadimitriou and Marcella Rietschel and Alessandro Serretti and Daniel Souery and Sofie Van Gestel and Christine Van Broeckhoven and Julien Mendlewicz},
  journal={Molecular Psychiatry},
Substantial evidence supports a role for dysfunction of brain serotonergic (5-HT) systems in the pathogenesis of major affective disorder, both unipolar (recurrent major depression) and bipolar.1 Modification of serotonergic neurotransmission is pivotally implicated in the mechanism of action of antidepressant drugs2 and also in the action of mood stabilizing agents, particularly lithium carbonate.3 Accordingly, genes that code for the multiple subtypes of serotonin receptors that have been… CONTINUE READING


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