Variability in timing of spontaneous calcium release in the intact rat heart is determined by the time course of sarcoplasmic reticulum calcium load.

@article{Wasserstrom2010VariabilityIT,
  title={Variability in timing of spontaneous calcium release in the intact rat heart is determined by the time course of sarcoplasmic reticulum calcium load.},
  author={John Andrew Wasserstrom and Yohannes Shiferaw and Wei Chen and Satvik Ramakrishna and Heetabh Patel and James E. Kelly and Matthew J O'Toole and Amanda Pappas and Nimi Chirayil and Nikhil Bassi and Lisa Akintilo and Megan Yi Jun Wu and Rishi Arora and Gary L. Aistrup},
  journal={Circulation research},
  year={2010},
  volume={107 9},
  pages={1117-26}
}
BACKGROUND Abnormalities in intracellular calcium (Ca) cycling during Ca overload can cause triggered activity because spontaneous calcium release (SCR) activates sufficient Ca-sensitive inward currents to induce delayed afterdepolarizations (DADs). However, little is known about the mechanisms relating SCR and triggered activity on the tissue scale. METHODS AND RESULTS Laser scanning confocal microscopy was used to measure the spatiotemporal properties of SCR within large myocyte populations… CONTINUE READING