Variability in the pKa of histidine side-chains correlates with burial within proteins.

@article{Edgcomb2002VariabilityIT,
  title={Variability in the pKa of histidine side-chains correlates with burial within proteins.},
  author={Stephen P. Edgcomb and Kenneth P. Murphy},
  journal={Proteins},
  year={2002},
  volume={49 1},
  pages={1-6}
}
Acidic pKas of histidines buried within the protein interior are frequently rationalized on the contradictory basis of either polar interactions within the protein or the effects of a hydrophobic environment. To examine these relationships, we surveyed the buried surface area, depth of burial, polar interactions, and crystallographic temperature factors of histidines of known pKa. It has been found that buried environments of histidines do not always result in acidic pKas. Instead, the… CONTINUE READING

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