Variability in strength of red yeast rice supplements purchased from mainstream retailers

@article{Cohen2017VariabilityIS,
  title={Variability in strength of red yeast rice supplements purchased from mainstream retailers},
  author={Pieter A. Cohen and Bharathi Avula and Ikhlas A. Khan},
  journal={European Journal of Preventive Cardiology},
  year={2017},
  volume={24},
  pages={1431 - 1434}
}
The United States Food and Drug Administration (FDA) has introduced manufacturing standards for dietary supplements, including red yeast rice, to assure their identity, purity, strength, and composition. One supplement commonly used to self-treat high cholesterol, red yeast rice, may contain monacolin K, an ingredient identical to prescription lovastatin. We examined whether FDA’s manufacturing standards led to standard concentrations of the statin monacolin K in red yeast rice supplements. We… Expand
Food supplements with red yeast rice: More regulations are needed.
  • G. De Backer
  • Medicine
  • European journal of preventive cardiology
  • 2017
TLDR
Large variations in the quantity of monacolin K in RYR supplements and a possible inter-individual variation in the response to a given dose of RYR raise questions as to the effectiveness and the safety of these supplements. Expand
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The Panel was unable to identify a dietary intake of monacolins from RYR that does not give rise to concerns about harmful effects to health, for the general population, and as appropriate, for vulnerable subgroups of the population. Expand
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Notwithstanding recognized limitations, these findings strengthen the importance of exploring multiple databases in safety assessment of RYR products, which should be monitored by clinicians for muscular and hepatic safety, and call for urgent review by policymakers to harmonize their regulatory status. Expand
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TLDR
Overall, the data represent a further proof that a strict legislation regulating the production and marketing of dietary supplements and a close monitoring of these products by food and drug regulatory organs is mandatory. Expand
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  • 2020
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TLDR
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TLDR
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