Variability in platelet responsiveness to clopidogrel among 544 individuals.

  title={Variability in platelet responsiveness to clopidogrel among 544 individuals.},
  author={Victor L. Serebruany and Steven R. Steinhubl and Peter B. Berger and Alex I. Malinin and Deepak L Bhatt and Eric J. Topol},
  journal={Journal of the American College of Cardiology},
  volume={45 2},
OBJECTIVES We sought to describe the responses of patients to clopidogrel using ex vivo measures of platelet aggregation and activation in a large, heterogeneous population. BACKGROUND Recently, a number of reports, using various definitions, have dichotomized patients who are treated with clopidogrel into a minority of "non-responders" and a majority of "responders." Such classifications imply that treatment leads to an all-or-none response, with potentially important clinical implications… CONTINUE READING