Variability in free mycophenolic acid exposure in adult liver transplant recipients during the early posttransplantation period.

@article{Benichou2010VariabilityIF,
  title={Variability in free mycophenolic acid exposure in adult liver transplant recipients during the early posttransplantation period.},
  author={Anne Sophie Benichou and Beno{\^i}t Blanchet and Filom{\'e}na Conti and Maryline Hornecker and Denis K.H. Bernard and Fabrice Taieb and Olivier Scatton and Halim Abbas and Laura Harcouet and Alain Dauphin and Yvon Calmus and Michel Tod},
  journal={Journal of clinical pharmacology},
  year={2010},
  volume={50 10},
  pages={
          1202-10
        }
}
Mycophenolate mofetil (MMF) pharmacokinetics variability in liver transplant recipients during the early posttransplantation period may be related to changes in mycophenolic acid (MPA) protein binding. This study aimed at characterizing the variation of free MPA exposure with respect to time since transplantation. Three groups (A, B, C) were compared. The median posttransplantation time was 12 days (A, n = 26 pharmacokinetic sessions), 36 days (B, n = 25), and 867 days (C, n = 21). The median… CONTINUE READING
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