Variability in erythrocyte fructosamine 3-kinase activity in humans correlates with polymorphisms in the FN3K gene and impacts on haemoglobin glycation at specific sites.

@article{Delpierre2006VariabilityIE,
  title={Variability in erythrocyte fructosamine 3-kinase activity in humans correlates with polymorphisms in the FN3K gene and impacts on haemoglobin glycation at specific sites.},
  author={Ghislain Delpierre and Maria Veiga-da-Cunha and Didier Vertommen and Martin Buysschaert and Emile van Schaftingen},
  journal={Diabetes & metabolism},
  year={2006},
  volume={32 1},
  pages={31-9}
}
BACKGROUND Part of the fructosamines that are bound to intracellular proteins are repaired by fructosamine 3-kinase (FN3K). Because subject-to-subject variations in erythrocyte FN3K activity could affect the level of glycated haemoglobin independently of differences in blood glucose level, we explored if such variability existed, if it was genetically determined by the FN3K locus on 17q25 and if the FN3K activity correlated inversely with the level of glycated haemoglobin. RESULTS The mean… CONTINUE READING