Variability in Tidal Volume Affects Lung and Cardiovascular Function Differentially in a Rat Model of Experimental Emphysema

@inproceedings{Wierzchon2017VariabilityIT,
  title={Variability in Tidal Volume Affects Lung and Cardiovascular Function Differentially in a Rat Model of Experimental Emphysema},
  author={Caio G. R. S. Wierzchon and Gisele de Ara{\'u}jo Padilha and Nazareth de Novaes Rocha and Robert Huhle and Mariana S. Coelho and C{\'i}ntia Lourenço Santos and Raquel Souza Santos and Cynthia dos Santos Samary and Fernanda R. G. Silvino and Paolo Pelosi and Marcelo Gama de Abreu and Patricia R M Rocco and Pedro L Silva},
  booktitle={Front. Physiol.},
  year={2017}
}
In experimental elastase-induced emphysema, mechanical ventilation with variable tidal volumes (VT) set to 30% coefficient of variation (CV) may result in more homogenous ventilation distribution, but might also impair right heart function. We hypothesized that a different CV setting could improve both lung and cardiovascular function. Therefore, we… CONTINUE READING