Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John’s wort

@article{GdtelArmbrust2007VariabilityIP,
  title={Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John’s wort},
  author={Ute G{\"o}dtel-Armbrust and Annegret Metzger and Ulrike Kroll and Olaf Kelber and Leszek Wojnowski},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2007},
  volume={375},
  pages={377-382}
}
St. John’s wort (SJW, Hypericum perforatum) is a well-tolerated herbal medicine widely used for the treatment of mild and moderate depressions. In the last 5 years, SJW has been implicated in drug interactions, which are largely mediated by the induction of the drug metabolizing enzymes, especially CYP3A4. There is still some controversy regarding the exact mechanism of induction and the identity of the SJW constituents involved. We investigated in LS174T cells the induction of CYP3A4 by ten… CONTINUE READING
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