Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG.

@article{Maas2008VardenafilPI,
  title={Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG.},
  author={Ole Maas and Ulrike Donat and Monika Astrid Frenzel and Thomas R{\"u}tz and Heyo Klaus Kroemer and Stephan Burkhart Felix and Thomas Krieg},
  journal={British journal of pharmacology},
  year={2008},
  volume={154 1},
  pages={25-31}
}
BACKGROUND AND PURPOSE The type-5 PDE inhibitor vardenafil reduces myocardial infarct size in situ, following ischemia/reperfusion, when applied at reperfusion in animal models. Little is known about the underlying protective signaling. Here, we test whether vardenafil is protective in rat isolated hearts and in a cell model of calcium stress. EXPERIMENTAL APPROACH Infarct size in rat isolated hearts was measured after a 30 min regional ischemia and 120 min reperfusion. Vardenafil (1 nM-1… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…