Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets.

@article{Toque2008VardenafilBN,
  title={Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets.},
  author={Haroldo A. Toque and Cleber E. Teixeira and Fernanda B M Priviero and Rafael P. Morganti and Edson Antunes and Gilberto de Nucci},
  journal={British journal of pharmacology},
  year={2008},
  volume={154 4},
  pages={
          787-96
        }
}
  • Haroldo A. Toque, Cleber E. Teixeira, +3 authors Gilberto de Nucci
  • Published in
    British journal of…
    2008
  • Chemistry, Medicine
  • BACKGROUND AND PURPOSE Phosphodiesterase type-5 (PDE5) inhibitors constitute a novel and important therapeutic option for the treatment of pulmonary hypertension. The effects of the PDE5 inhibitors sildenafil, tadalafil and vardenafil on rabbit isolated pulmonary artery ring preparations and on intracellular Ca2+ concentration of thrombin-stimulated human platelets were investigated. EXPERIMENTAL APPROACH Rabbit pulmonary artery rings were mounted in 10 mL organ bath containing Krebs solution… CONTINUE READING

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