Vardenafil, but not sildenafil or tadalafil, has calcium‐channel blocking activity in rabbit isolated pulmonary artery and human washed platelets

@article{Toque2008VardenafilBN,
  title={Vardenafil, but not sildenafil or tadalafil, has calcium‐channel blocking activity in rabbit isolated pulmonary artery and human washed platelets},
  author={H. A. Toque and C. Teixeira and F. Priviero and R. P. Morganti and E. Antunes and G. De Nucci},
  journal={British Journal of Pharmacology},
  year={2008},
  volume={154}
}
Phosphodiesterase type‐5 (PDE5) inhibitors constitute a novel and important therapeutic option for the treatment of pulmonary hypertension. The effects of the PDE5 inhibitors sildenafil, tadalafil and vardenafil on rabbit isolated pulmonary artery ring preparations and on intracellular Ca2+ concentration of thrombin‐stimulated human platelets were investigated. 
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